Figure 7.

Effect of metallothionein on PPE-induced oxidative stress. (A,B) Wildtype (WT) and MT-1 and -2 gene knockout (MT-KO) mice were treated with sterile saline (Cont) or PPE (10 U/kg) only once, on day 0. (A) Sections of pulmonary tissue were prepared 72 h after PPE administration and subjected to 8-hydroxydeoxyguanosine (8-OHdG) staining (scale bar = 200 µm). (B) The 8-OHdG-positive area was measured. Values are the mean ± S.E.M. ** or ## p < 0.01 (**, vs. Control; ##, vs. WT). The experiments that produced the data shown in this figure were performed at least twice.