Table 3.
Association of miRNA expression levels with selected cytokines (secondary outcome).
| Cytokine | Sex | miR-10b-5p | q-Value | miR-26b-3p | q-Value | miR-31-5p | q-Value | miR-576-5p | q-Value |
|---|---|---|---|---|---|---|---|---|---|
| TNF-α | Boys | 2.5 (2.0–3.0) | 1.000 | 3.0 (2.6–3.4) | 0.006 | 1.3 (0.3–2.2) | 0.963 | 7.7 (6.4–9.0) | 0.005 |
| Girls | 3.2 (2.4–4.0) | 0.635 | 2.4 (−0.4–5.2) | 1.000 | 1.5 (1.0–2.1) | 0.485 | 7.2 (6.1–8.2) | 0.730 | |
| IL1-Ra | Boys | 2.6 (2.1–3.1) | 0.810 | 3.0 (2.6–3.4) | 0.005 | 1.1 (−0.03–2.2) | 0.393 | 7.9 (6.4–9.4) | 0.023 |
| Girls | 3.3 (2.5–4.1) | 0.558 | 2.3 (−0.8–5.5) | 1.000 | 1.6 (0.9–2.2) | 1.000 | 6.6 (5.3–7.8) | 0.735 | |
| IL-6 | Boys | 2.6 (2.0–3.2) | 0.743 | 3.0 (2.1–4.0) | 0.461 | 0.8 (−0.5–2.0) | 0.963 | 7.1 (4.2–10.0) | 0.932 |
| Girls | 3.3 (2.5–4.1) | 0.949 | 2.2 (−0.9–5.3) | 0.732 | 1.6 (0.9–2.2) | 0.692 | 6.8 (5.7–8.0) | 0.625 | |
| IL-8 | Boys | 2.4 (1.8–3.0) | 0.927 | 2.9 (2.5–3.3) | 0.005 | 1.2 (0.2–2.2) | 0.410 | 7.2 (5.6–8.9) | 0.021 |
| Girls | 3.3 (2.4–4.1) | 0.649 | 2.5 (−0.5–5.4) | 1.000 | 1.6 (1.1–2.1) | 1.000 | 7.3 (6.2–8.4) | 0.856 | |
| IL-15 | Boys | 2.6 (2.1–3.1) | 0.588 | 2.9 (2.5–3.3) | 0.005 | 1.2 (0.1–2.3) | 0.890 | 7.5 (5.9–9.1) | 0.015 |
| Girls | 3.3 (2.6–4.0) | 0.512 | 2.3 (0.9–2.3) | 0.912 | 1.6 (0.9–2.2) | 0.856 | 6.8 (5.7–8.0) | 0.908 |
Data are expressed as mean (CIs). Covariates: Country of residence, age, BMI z-score, pubertal status. q-values are BH-adjusted p-values. Values in bold indicate statistically significant results.