Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Inhibition of CYP450 isoforms by INH at 50 μM (A) and 0 to 250 μM (B) in HLMs. The activity of each isoform was measured by isoform-specific substrate reaction probes at approximately their respective Km values: 60 μM for phenacetin O-deethylation (CYP1A2); 25 μM for dextromethorphan (CYP2D6); 25 μM for midazolam 4-hydroxylation (CYP3A); 50 μM for omeprazole (CYP2C19); 50 μM for tolbutamide (CYP2C9); and 25 μM for chlorzoxazone (CYP2E1). Data represent averages of duplicates.
