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Dixon plots for the inhibition of CYP2C19-catalyzed omeprazole 5-hydroxylation by INH (0 to 250 μM) in HLMs (A) and S-mephenytoin 4-hydroxylation by INH (0 to 100 μM) in recombinant human CYP2C19 (B). Each point represents the average of duplicate determinations.
