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Dixon plots for the inhibition of CYP3A-catalyzed omeprazole sulfone formation (A), midazolam 4-hydroxylation (B), and dextromethorphan N-demethylation (C) by INH in HLMs. The INH concentrations used were 0 to 100 μM (A and B) and 0 to 250 μM (C). Each point represents the average of duplicate determinations.
