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Inhibition of CYP2E1-mediated chlorzoxazone 6-hydroxylation by INH. (A) Percent inhibition of CYP2E1 activity (with chlorzoxazone [25 μM]) by INH and diethyldithiocarbamate (DEDTC) as a positive control in HLMs; (B) Representative Dixon plots for the inhibition of CYP2E1 activity by INH (25 to 250 μM) in HLMs. Data represent averages of duplicates.
