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Inhibition of CYP2D6-catalyzed dextromethorphan O-demethylation and CYP1A2-catalyzed O-deethylation by INH in HLMs. (A) Dixon plots for the inhibition of CYP2D6 (INH, 0 to 250 μM); (B) percent inhibition of CYP1A2 (with phenacetin [25 and 50 μM] as a substrate) (INH, 0 to 250 μM). Each point represents the average of duplicate determinations.
