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. 2022 Apr 10;23(8):4174. doi: 10.3390/ijms23084174

Figure 2.

Figure 2

GZ17-6.02 suppresses the growth and invasion of GSCs. (a) Representative dose–response curves of two GSC lines tested against various concentrations of GZ17-6.02. (b) Representative images of three-dimensional Matrigel invasion assays in a semi-solid matrix showing inhibition of invasive capacity of D10-0171 and D317 by GZ17-6.02. This assay also demonstrates highly invasive behavior of D10-0171 and an apparent lack of invasive capacity of D317. (c) Quantification of three-dimensional Matrigel invasion assays for D10-0171 showing percent area occupied by tumor spheroids and their radial projections at varying concentrations of GZ17-6.02. (d) Quantification of three-dimensional Matrigel invasion assays for D317 showing percent area occupied by tumor spheroids and their radial projections at varying concentrations of GZ17-6.02. * p < 0.05, *** p < 0.001. DMSO, dimethyl sulfoxide.