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. 2022 Apr 10;23(8):4174. doi: 10.3390/ijms23084174

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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GZ17-6.02 downregulates unsaturated fatty acid biosynthesis. (a) Heatmap of mRNA expression of select unsaturated fatty acid biosynthesis related genes in control and GZ17-6.02 treated D10-0171 GSCs. (b) Heatmap of mRNA expression of select unsaturated fatty acid biosynthesis related genes in control and GZ17-6.02 treated D317 GSCs. The p-values shown are false discovery rate-adjusted p-values. (c) GeneMANIA functional association gene network for select unsaturated fatty acid biosynthesis related genes. Genes shown in blue are downregulated by GZ17-6.02 in both D10-0171 and D317, while associated genes are shown in gray. Physical and genetic interactions are shown in pink and green, respectively, while co-expression and co-localization between genes are shown in purple and blue, respectively. Thicker lines indicate stronger associations. (d) GSVA comparison of positive regulation of unsaturated fatty acid biosynthetic process in control and GZ17-6.02 treated D10-0171 and D317 GSCs showing a significant decrease in both following GZ17-6.02 treatment. (e) GSVA comparison of unsaturated fatty acid biosynthetic process in control and GZ17-6.02 treated D10-0171 and D317 GSCs showing a significant decrease in both following GZ17-6.02 treatment. Fold changes shown are log base 2-fold changes. * p < 0.05, ** p < 0.01, *** p < 0.001. GZ, GZ17-6.02; GSVA, gene set variation analysis; C, control.