Table 3.
Univariate and multivariate Cox regression analyses of the 7-Gene Algorithm and clinicopathological factors for prediction of progression-free survival (PFS) in the MSK cohort (n = 471) and the TCGA cohort (n = 191).
| Univariate | Multivariate | |||
|---|---|---|---|---|
| HR (95% CI) | p Value | HR (95% CI) | p Value | |
| Prediction of PFS in the MSK Cohort (n = 471) | ||||
| 7-Gene Algorithm | 7.5 (3.5–15.9) | <0.0001 | 8.9 (4.0–20.1) | <0.0001 |
| Cancer stage | 1.3 (0.9–1.9) | 0.128 | 1.1 (0.7–1.5) | 0.755 |
| Adjuvant therapies | 1.1 (0.8–1.3) | 0.877 | 1.1 (0.8–1.4) | 0.536 |
| Surgery on primary tumor | 0.8 (0–1.0) | 0.013 | 0.7 (0–0.9) | 0.002 |
| MSI | 0.7 (0.5–1.1) | 0.097 | 0.6 (0–0.9) | 0.009 |
| Prediction of PFS in the TCGA Cohort (n = 191) | ||||
| 7-Gene Algorithm | 16.9 (7.2–39.6) | <0.0001 | 16.9 (7.2–39.7) | <0.0001 |
| Cancer stage | 1.2 (0.5–2.7) | 0.723 | 1.3 (0.6–3.1) | 0.539 |
| Adjuvant therapies | 3.0 × 10−7 (0-Inf) | 0.997 | 1.7 × 10−6 (0-Inf) | 0.996 |
HR: hazard ratio; CI: confidence interval; MSI: microsatellite instability.