Table 4.

Univariate and multivariate Cox regression analyses of the 7-Gene Algorithm and clinicopathological factors for prediction of progression-free survival in mCRC patients (n = 388).

	Univariate		Multivariate
	HR (95% CI)	p Value	HR (95% CI)	p Value
7-Gene Algorithm	16.9 (4.2–68.0)	<0.0001	17.6 (4.4–70.8)	<0.0001
Cancer stage	1.3 (0.9–2.0)	0.194	1.1 (0.7–1.7)	0.735
Adjuvant therapies	1.1 (0.8–1.4)	0.671	0.7 (0–1.6)	0.317
Surgery on primary tumor	0.8 (0–1.0)	0.044	0.7 (0–0.9)	0.003
MSI	0.4 (0–0.7)	0.002	0.4 (0–0.8)	0.003

HR: hazard ratio; CI: confidence interval; MSI: microsatellite instability.