Table 2.

Intra-group comparison of parameters, probing pocket depth, clinical attachment level and depth of the defect at various time points

Parameter	Group	Time point	Mean±SD	ANOVA		Post hoc - Bonferroni correction
				F	P	Pairs	MD (SE)	P
PPD	Control	BL	7.0±1.1	176.35	<0.0005*	BL versus 3M	1.40 (0.13)	0.0005*
		3M	5.6±1.1			BL versus 6M	2.33 (0.13)	0.0005*
		6M	4.7±1.0			3M versus 6M	0.93 (0.12)	0.0005*
	Test	BL	8.13±1.30	342.31	<0.0005*	BL versus 3M	2.73 (0.18)	0.0005*
		3M	5.40±1.06			BL versus 6M	4.13 (0.17)	0.0005*
		6M	4.00±0.93			3M versus 6M	1.40 (0.13)	0.0005*
CAL	Control	BL	6.27±1.28	65.28	<0.0005*	BL versus 3M	1.13 (0.13)	0.0005*
		3M	5.13±1.19			BL versus 6M	1.60 (0.16)	0.0005*
		6M	4.67±1.05			3M versus 6M	0.47 (0.13)	0.011*
	Test	BL	7.33±1.18	154.90	<0.0005*	BL versus 3M	1.80 (0.11)	0.0005*
		3M	5.53±1.06			BL versus 6M	2.87 (0.19)	0.0005*
		6M	4.47±0.74			3M versus 6M	1.07 (0.18)	0.0005*
DD	Control	BL	1.84±0.86	10.32	0.002*	BL versus 3M	0.41 (0.16)	0.059
		3M	1.42±0.58			BL versus 6M	0.74 (0.21)	0.009*
		6M	1.10±0.42			3M versus 6M	0.33 (0.11)	0.031
	Test	BL	3.08±1.02	49.23	<0.0005*	BL versus 3M	0.59 (0.16)	0.006*
		3M	2.49±1.02			BL versus 6M	1.72 (0.19)	0.0005*
		6M	1.35±0.68			3M versus 6M	1.14 (0.18)	0.0005*

*Significance set at α=0.05. Control: Control group treated with open flap debridement only; Test: Test group treated with open flap debridement and Platelet-rich fibrin matrix; ANOVA: Repeated measures ANOVA, adjusted for lack of sphericity by Greenhouse-Geisser correction. PPD: Probing pocket depth; CAL: Clinical attachment level; DD: Depth of the defect; BL: Baseline; 3M: 3 months posturgery; 6M: 6 months postsurgery; SD: Standard deviation; MD: Difference of means; SE: Standard error