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Pharmacokinetic parameters of JIN-001 following single oral administration of F1, F2 and F4 formulations (20 mg) to beagle dogs (n = 9).
| Parameter | F1 | F2 | F4 |
|---|---|---|---|
| t1/2 | 9.22 ± 2.82 | 11.35 ± 3.16 | 14.28 ± 6.91 |
| Tmax (h) | 0.47 ± 0.23 | 0.69 ± 0.51 | 0.47 ± 0.15 |
| Cmax (ng·h/mL) | 9.25 ± 1.98 | 8.92 ± 2.75 | 11.29 ± 4.47 |
| AUC0–48h (ng·h/mL) | 67.34 ± 25.26 | 72.07 ± 23.65 | 64.88 ± 18.57 |
| AUCinfinity (ng·h/mL) | 71.25 ± 26.50 | 78.48 ± 25.64 | 82.37 ± 28.79 |
