Table 2.
Lipids commonly used for gene transfer.
| Lipid | Abbreviation | Polar Domain | Nonpolar Domain | Feature |
|---|---|---|---|---|
| N-[1-(2,3-Dioleyloxy)propyl]N,N,N-trimethylammonium chloride | DOTMA | Quaternary ammonium | Unsaturated aliphatic | Cationic lipid |
| 1,2-Dioleoyloxy-3-trimethylammonium-propane | DOTAP | Quaternary ammonium | Unsaturated aliphatic | Cationic lipid |
| Dioctadecylamidoglycylspermine | DOGS | Polyamine | Aliphatic | Cationic lipid |
| Cetyltrimethylammonium bromide | CTAB | Quaternary ammonium | Single-tail aliphatic | Cationic lipid |
| 2,3-Dioleyloxy-N-[2(sperminecarboxamido)-ethyl]-N,N-dimethyl-1-propanaminium trifluoroacetate | DOSPA | Polyamine | Unsaturated aliphatic | Cationic lipid |
| 1,2-Dioleyl-3-trimethylammonium-propane | DOPA | Quaternary ammonium | Unsaturated aliphatic | Cationic lipid |
| Dimyristooxypropyl dimethyl hydroxyethyl ammonium bromide | DMRIE | Quaternary ammonium | Aliphatic | Cationic lipid |
| Dimethyldioctadecylammonium bromide | DDAB | Quaternary ammonium | Aliphatic | Cationic lipid |
| 1,2-Distearyloxy-N,N-dimethyl-3-aminopropane | DSDMA | Secondary amine | Aliphatic | Cationic lipid |
| 1,2-Dimyristoyl-trimethylammoniumpropane | DMTAP | Quaternary ammonium | Aliphatic | Cationic lipid |
| 1,2-Distearoyl-sn-glycero-3-ethylphosphocholine | DSEPC | Quaternary ammonium | Aliphatic | Cationic lipid |
| N-Palmitoyl d-erythro-sphingosyl carbamoyl-spermine | CCS | Spermine | Unsaturated aliphatic | Cationic lipid |
| 1,3-Dioleoxy-2-(6-carboxy-spermyl)-propylamide | DOSPER | Polyamine | Unsaturated aliphatic | Cationic lipid |
| (1,2-dioleoyl-3-dimethyl-hydroxyethyl ammonium bromide) | DORIE | Quaternary ammonium | Unsaturated aliphatic | Cationic lipid |
| (1,2-dioleoyloxypropyl-3-dimethyl-hydrox yethyl ammonium chloride) | DORI | Quaternary ammonium | Unsaturated aliphatic | Cationic lipid |
| N,N-dioleyl-N,N-dimethylammonium Chloride | DODAC | Quaternary ammonium | Aliphatic | Cationic lipid |
| Bis-guanidium-tren-cholesterol | BGTC | Guanidinium-spermidine- | Steroid-based | Cationic lipid |
| 3β-[N-(N′,N′-Dimethylaminoethane)-carbamoyl]cholesterol | DC-Chol | Tertiary amine | Steroid-based | Cationic lipid |
| Octadecenolyoxy[ethyl-2-heptadecenyl-3 hydroxyethyl] imidazolinium chloride | DOTIM | Heterocycle (imidazole) | Unsaturated aliphatic | Cationic lipid |
| 1,2-dioleoyl-sn-glycerol-3-ethylphosphocholine | DOEPC | Ethylphosphocholine | Aliphatic | Cationic lipid |
| O,O′-Dimyristyl-N-lysyl aspartate | DMKE | Primary amine | Aliphatic | Cationic lipid |
| O,O′-dimyristyl N-lysylaspartate | DMKD | Primary amine | Aliphatic | Cationic lipid |
| N-t-Butyl-N0-tetradecyl-3-tetradecylaminopropionamidine | diC14-amidine | Imine group | Aliphatic | Cationic lipid |
| N-(4-carboxybenzyl)-N,N-dimethyl-2,3-bis(oleoyloxy)propan-1-aminium | DOBAQ | Quaternary ammonium | Unsaturated aliphatic | Cationic lipid |
| 1,2-dioleyloxy-3-dimethylaminopropane | DODMA | Tertiary amine | Unsaturated aliphatic | Cationic lipid |
| 6-Lauroxyhexyl ornithinate | LHON | Ornithine | Single-tail aliphatic | Cationic lipid |
| 1,2-Dioleoyl-sn-glycero-3-phosphatidylcholine | DOPC | - | Phosphatidylcholine | Helper lipid |
| 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine | DOPE | - | Phosphatidylcholine | Helper lipid |
| Cholesterol | CHOL | - | Steroid | Helper lipid |