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. 2022 Apr 12;23(8):4262. doi: 10.3390/ijms23084262

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The C-6 treatment decreases the levels of protein aggregation and phosphorylated α-synuclein in the L-61 mice. (A) A few example images show the different levels of protein aggregates in Thioflavin-T stain and phosphorylated Ser-129-α-synuclein in the striatum. The oral treatment reduced the levels of protein aggregates in Thioflavin-T (B) and phosphorylated Ser-129-α-synuclein (C) in the striatum of transgenic mice. One-way ANOVA with Dunnett’s test to compare the intensities of Thioflavin-T stain and phospho-Ser129-α-synuclein label present across the groups with or without treatment (#) (n = 7–8/group). **: p < 0.01, ***: p < 0.001 and ****: p < 0.0001. ns: not significant.