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. 2022 Apr 12;23(8):4262. doi: 10.3390/ijms23084262

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The compound-6 treatment alleviates motor dysfunctions in PFF-injected mice. (A) The schematic diagram shows the timeline of gavaging and behavioral test scheduled in PFF-injected mice. The oral treatment for 5–6 weeks improved the latency on rotarod (B), enhanced nesting capabilities (C), improved grooming (D), reduced the climb-down time on the pole test (E), and alleviated hindlimb clasping (F). One-way ANOVA with Dunnett’s test was applied to compare the treated groups with that of PFF-only mice (#) (n = 7–8/group). *: p < 0.05, **: p < 0.01 and ****: p < 0.0001. ns: not significant.