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. 2022 Apr 12;23(8):4262. doi: 10.3390/ijms23084262

Figure 9.

Figure 9

The C-6 treatment prevents or even recovers from dopaminergic neuronal damage in the SNc and increases TH intensity in the STr. (A) The examples of IHC show an increase in TH intensity in the STr and higher number of TH+ neurons in the SNc from mice treated with 25 mg/kg dose, compared with PFF only. (B) The C-6 treatment at 25 mg/kg enhanced the level of TH+ in the striatum, compared with PFF only (n = 7–8/group). (C) The number of TH+ neurons in the SNc is significantly higher with the C-6 treatment than PFF only (n = 7–8/group). One-way ANOVA with Dunnett’s test was used to compare the intensity of TH+ cells in the striatum and TH+ cell number in the SNc, compared with PBS-vehicle- or PFF-vehicle (#)-treated mice. ***: p < 0.001 and ****: p < 0.0001. ns: not significant.