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. 2022 Apr 18;23(8):4447. doi: 10.3390/ijms23084447

Figure 2.

Figure 2

Reduced ventricular dilatation induced by severe IVH observed after transplantation of thrombin- preconditioned MSCs. Transplantation of thrombin-preconditioned MSCs reduced ventricular dilatation after IVH induction. (A) Serial brain magnetic resonance images of the four groups and (B) ventricle-to-whole brain volume ratio (n = 18, 29, 23, 28 in the NC group, IC group, INM group and ITM group, respectively). Data are expressed as means ± SEM. * p < 0.05 and ** p < 0.01 compared to the NC group, # p < 0.05 compared to the IC group. NC, normal control; IC, IVH control; INM, IVH with transplantation of naïve MSCs; ITM, IVH with transplantation of thrombin-preconditioned MSCs; IVH, intraventricular hemorrhage; MSCs, mesenchymal stem cells; SEM, standard error of the mean.