Figure 1.

Schematic representation of NXN redox-sensitive interactions. NXN directly interacts with several proteins, including DVL, PFK1, PP2A, MYD88, FLII, SEC63 and CAMK2A, which participate in the regulation of the activity of different signaling pathways. Since only some interaction domains between NXN and DVL, PP2A and SEC63 have been described so far, the image shows a hypothetical representation of the NXN-protein interactions. The interaction domains already characterized are described below.