. 2022 Mar 29;11(4):458. doi: 10.3390/antibiotics11040458

Table 2.

Stability of antibiotics in polypropylene syringes and amoxicillin in polyolefin bags at 20–25 °C for continuous intravenous infusion measured by HPLC.

			Mean % of Initial Concentration ± RSD * %
Antibiotic	Conc.	Solvent	T0 h	T4 h	T6 h	T8 h	T12 h	T24 h	T48 h
Amoxicillin **	20 mg/mL	NS	100 ± 1.19	-	96.7 ± 1.77	-	94.1 ± 0.66	87.5 ± 0.45	78.5 ± 1.52
Aztreonam	125 mg/mL	NS ***	100.0 ± 2.38	-	98.7 ± 0.90	-	-	95.3 ± 1.79	92.7 ± 1.95
Aztreonam	125 mg/mL	D5W ****	100.0 ± 0.47	-	99.5 ± 0.77	-	-	98.1 ± 1.42	95.7 ± 0.57
Cefazolin	125 mg/mL	NS	100.0 ± 2.35	-	103.3 ± 1.67	-	-	100.0 ± 1.98	100.6 ± 1.95
Cefazolin	125 mg/mL	D5W	100.0 ± 0.91	-	99.8 ± 3.11	-	-	99.4 ± 1.99	97.7 ± 2.10
Cefepime	110 mg/mL	NS	100.0 ± 2.15	-	98.1 ± 0.61	-	-	94.8 ± 1.85	87.3 ± 0.82
Cefepime	110 mg/mL	D5W	100.0 ± 1.78	-	94.7 ± 0.93	-	-	90.6 ± 0.43	85.5 ± 1.80
Cefiderocol	62.5 mg/mL	NS	100.0 ± 1.30	-	-	-	94.2 ± 1.11	91.6 ± 0.98	85.7 ± 2.24
Cefiderocol	62.5 mg/mL	D5W	100.0 ± 1.43	-	-	-	97.4 ± 0.68	94.0 ± 0.73	87.1 ± 0.53
Cefotaxime	83.3 mg/mL	NS	100.0 ± 2.15	-	95.3 ± 1.50	-	92.2 ± 1.93	87.2 ± 2.05	-
	83.3 mg/mL	D5W	100.0 ± 1.48	-	95.4 ± 1.04	-	93.0 ± 1.43	88.3 ± 1.45	-
	125 mg/mL	NS	100.0 ± 1.70	-	95.7 ± 1.38	-	95.2 ± 1.23	51.4 ± 1.53	-
	125 mg/mL	D5W	100.0 ± 1.21	-	97.4 ± 2.00	-	94.9 ± 1.18	-	-
Cefoxitin	125 mg/mL	NS	100.0 ± 1.88	-	99.5 ± 0.79	-	97.3 ± 3.73	94.4 ± 1.60	89.8 ± 2.03
Cefoxitin	125 mg/mL	D5W	100.0 ± 1.79	-	98.9 ± 1.32	-	96.4 ± 3.00	93.8 ± 1.80	89.6 ± 2.14
Ceftazidime	125 mg/mL	NS	100.0 ± 0.94	-	-	98.3 ± 2.04	-	94.9 ± 1.80	86.5 ± 1.89
Ceftazidime	125 mg/mL	D5W	100.0 ± 1.69	-	-	95.1 ± 1.06	-	89.0 ± 0.78	82.2 ± 0.44
Ceftazidime	125 mg/mL	NS	100.0 ± 0.98	-	-	-	96.7 ± 0.31	95.2 ± 1.33	87.4 ± 1.22
Ceftazidime	125 mg/mL	D5W	100.0 ± 1.26	-	-	-	98.1 ± 0.86	91.7 ± 0.55	87.1 ± 1.36
Avibactam	31.25 mg/mL	NS	100.0 ± 0.86	-	-	-	96.4 ± 0.91	96.2 ± 1.77	91.0 ± 0.89
Avibactam	31.25 mg/mL	D5W	100.0 ± 1.47	-	-	-	99.1 ± 0.79	94.7 ± 0.77	93.0 ± 1.41
Ceftozolane	62.5 mg/mL	NS	100.0 ± 2.15	-	-	96.4 ± 2.25	-	93.9 ± 2.25	91.8 ± 1.52
Ceftozolane	62.5 mg/mL	D5W	100.0 ± 1.92	-	-	98.5 ± 1.55	-	96.2 ± 2.50	92.8 ± 0.54
Tazobactam	31.25 mg/mL	NS	100.0 ± 2.27	-	-	98.0 ± 2.57	-	99.0 ± 2.30	101.0 ± 2.34
Tazobactam	31.25 mg/mL	D5W	100.0 ± 2.09	-	-	100.0 ± 1.79	-	101.3 ± 2.74	102.3 ± 0.83
Cloxacillin	250 mg/mL	SWFI *****	100.0 ± 1.91	-	98.8 ± 1.70	-	-	96.2 ± 1.63	90.2 ± 1.45
	125 mg/mL	NS	100.0 ± 3.07	-	100.2 ± 1.93	-	-	97.2 ± 3.01	90.5 ± 2.73
	125 mg/mL	D5W	100.0 ± 1.48	-	100.0 ± 2.06	-	-	97.3 ± 1.47	90.1 ± 1.21
Meropenem	41.7 mg/mL	NS	100.0 ± 1.59	97.1 ± 0.66	-	93.0 ± 0.93	-	-	-
Meropenem	41.7 mg/mL	D5W	100.0 ± 1.52	93.8 ± 0.68	-	85.9 ± 0.74	-	-	-
Piperacillin	125 mg/mL	NS	100.0 ± 0.87	-	97.6 ± 0.24	-	-	92.8 ± 2.05	88.9 ± 1.37
Piperacillin	125 mg/mL	D5W	100.0 ± 1.11	-	100.0 ± 1.97	-	-	98.3 ± 1.23	97.5 ± 1.26
Piperacillin	125 mg/mL	NS	100.0 ± 0.96	-	-	101.3 ± 0.44	-	101 ± 1.26	98.1 ± 1.45
Piperacillin	125 mg/mL	D5W	100.0 ± 2.34	-	-	97.1 ± 0.59	-	95.9 ± 1.05	93.5 ± 0.68
Tazobactam	15.6 mg/mL	NS	100.0 ± 1.16	-	-	100.8 ± 0.40	-	101.1 ± 1.56	99.4 ± 1.52
Tazobactam	15.6 mg/mL	D5W	100.0 ± 2.26	-	-	96.3 ± 0.36	-	96.7 ± 1.49	95.1 ± 1.22
Temocillin	Unrealized in syringe
Vancomycin	62.5 mg/mL	NS	100.0 ± 1.65	-	99.8 ± 1.17	-	-	100.7 ± 1.05	99.5 ± 1.27
	62.5 mg/mL	D5W	100.0 ± 0.50	-	99.3 ± 1.03	-	-	98.2 ± 1.34	94.6 ± 2.88
	83.3 mg/mL	NS	100.0 ± 1.84	-	99.4 ± 1.28	-	-	98.4 ± 2.06	-
	83.3 mg/mL	D5W	100.0 ± 1.62	-	100.8 ± 0.92	-	-	96.0 ± 6.31	101.0 ± 0.86

* RSD: Relative standard deviation; ** packaged in polyolefin bag; *** NS: Normal Saline, **** D5W: Dextrose 5%, ***** Sterile Water for Injection.