Table 1.
Cohort descriptive statistics: values are mean ± SD or n (%).
| Demographic Characteristics | Overall (n = 571) |
Train Set (n = 399) |
Test Set (n = 172) |
p Value | Non R0 (n = 196) |
R0 (n = 375) |
p Value |
|---|---|---|---|---|---|---|---|
| Age (y) | 63.5 ± 11.2 | 63.6 ± 11 | 63.2 ± 11.7 | 0.71 | 65.6 ± 10.1 | 62.4 ± 11.6 | <0.001 |
| Histology | 0.217 | 0.008 | |||||
| Serous | 504 (0.88) | 350 (0.88) | 153 (0.89) | 186 (0.94) | 318 (0.85) | ||
| Mucinous | 13 (0.02) | 7 (0.017) | 6 (0.035) | 1 (0.005) | 12 (0.03) | ||
| Clear cell/endometrioid | 33 (0.06) | 23 (0.057) | 10 (0.058) | 6 (0.03) | 27 (0.07) | ||
| Miscellaneous | 22 (0.04) | 19 (0.047) | 3 (0.017) | 4 (0.02) | 18 (0.05) | ||
| Primary = 0/recurrent = 1 | 0.37 | ||||||
| Primary | 561 (0.98) | 370 (0.66) | 191 (0.32) | 0.7 | 192 (0.98) | 369 (0.98) | |
| Recurrent | 10 (0.02) | 7 (0.02) | 3 (0.02) | ||||
| Grade (G1 = 0/G3 = 1) | 516 (0.9) | 354 (0.89) | 162 (0.94) | 174 (0.89) | 342 (0.91) | 0.43 | |
| FIGO stage (S3 = 0/S4 = 1) | 157 (0.27) | 106 (0.27) | 51 (0.3) | 59 (0.3) | 98 (0.26) | 0.36 | |
| Performance status (WHO) | 0.74 | 0.001 | |||||
| 0 | 273 (0.48) | 192 (0.48) | 80 (0.46) | 70 (0.35) | 203 (0.54) | ||
| 1 | 212 (0.37) | 144 (0.36) | 68 (0.39) | 90 (0.46) | 122 (0.32) | ||
| 2 | 68 (0.12) | 50 (0.125) | 18 (0.1) | 28 (0.14) | 40 (0.1) | ||
| 3 | 19 (0.03) | 13 (0.276) | 6 (0.35) | 9 (0.04) | 10 (0.02) | ||
| Age of consultant (y) | 49.2 ± 6 | 49.3 ± 6 | 48.9 ± 6 | 0.46 | 49.2 ± 6.3 | 49.2 ± 5.9 | 0.99 |
| Timing of surgery | 0.6 | 0.38 | |||||
| Interval debulking surgery | 396 (0.69) | 278 (0.7) | 118 (0.69) | 141 (0.72) | 255 (0.68) | ||
| Primary debulking surgery | 175 (0.31) | 113 (0.64) | 62 (0.36) | 122 (0.7) | 53 (0.3) | ||
| Year | 0.7 | 0.012 | |||||
| 2014 | 91 (0.158) | 63 (0.158) | 27 (0.156) | 44 (0.22) | 47 (0.12) | ||
| 2015 | 93 (0.162) | 65 (0.163) | 28 (0.16) | 36 (0.18) | 57 (0.15) | ||
| 2016 | 108 (0.19) | 74 (0.185) | 34 (0.198) | 38 (0.19) | 70 (0.19) | ||
| 2017 | 96 (0.17) | 64 (0.16) | 32 (0.186) | 31 (0.16) | 65 (0.17) | ||
| 2018 | 82 (0.14) | 55 (0.138) | 27 (0.157) | 23 (0.12) | 59 (0.16) | ||
| 2019 | 102 (0.18) | 78 (0.195) | 24 (0.14) | 25 (0.13) | 77 (0.21) | ||
| Pre-treatment CA125 | 1572.7 ± 2993.2 | 1542.9 ± 3070.7 | 1641.8 ± 2812.9 | 0.7 | 1790.9 ± 3207 | 1458.7 ± 2873.1 | 0.22 |
| Pre-surgery CA125 | 411.79 ± 1170 | 387.3 ± 943.7 | 468.6 ± 1576.7 | 0.52 | 451 ± 931.7 | 391.3 ± 1277.7 | 0.52 |
| Size of largest disease bulk (cm) | 8.9 ± 5.58 | 9.0 ± 5.79 | 8.63 ± 5.09 | 0.43 | 9.79 ± 5.24 | 8.41 ± 5.7 | 0.004 |
| Peritoneal Carcinomatosis Index (PCI) | 7.39 ± 4.53 | 7.39 ± 4.52 | 7.4 ± 4.56 | 0.99 | 8.91 ± 4.31 | 6.6 ± 4.44 | <0.001 |
| Surgical Complexity Score (SCS) | 3.8 ± 2.12 | 3.79 ± 2.14 | 3.82 ± 2.09 | 0.89 | 3.1 ± 1.44 | 4.17 ± 2.32 | <0.001 |
| Time procedure (min) | 170.36 ± 77.48 | 170.1 ± 79.48 | 170.96 ± 72.85 | 0.9 | 161.84 ± 63.81 | 174.81 ± 83.47 | 0.039 |
| Site of largest tumour deposit | 0.28 | <0.001 | |||||
| Ovary | 298 (0.52) | 216 (0.54) | 82 (0.477) | 83 (0.42) | 215 (0.57) | ||
| Omentum | 258 (0.45) | 171 (0.43) | 86 (0.5) | 110 (0.56) | 148 (0.39) | ||
| Miscellaneous | 16 (0.03) | 12 (0.03) | 4 (0.023) | 4 (0.02) | 12 (0.03) | ||
| Intra Operative Mapping Score | 4.92 ± 1.99 | 4.95 ± 1.99 | 4.85 ± 2.01 | 0.58 | 5.96 ± 1.69 | 4.38 ± 1.93 | <0.001 |
| Ascites (intra-op) | 131 (0.23) | 93 (0.23) | 38 (0.22) | 49 (0.25) | 82 (0.22) | 0.458 |