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. 2022 Apr 4;12(4):576. doi: 10.3390/jpm12040576

Table 3.

Mean, standard deviation of incidence of diseases before and during COVID-19, and their difference in the subgroup by age.

Diseases Before COVID-19 During COVID-19 p-Values of Difference
Mean SD Mean SD Mean Variance
Age 20–39 years old
Depressive disorder 71,186.6 8426.6 98,224.07 8281.236 <0.001 * <0.001
Bipolar disorder 16,655.5 1345.4 20,394.40 1039.450 <0.001 * <0.001
Primary insomnia 23,920.1 1123.4 26,040.13 657.012 <0.001 * <0.001
Schizophrenia 25,253.5 535.2 24,169.13 364.634 <0.001 * <0.001
Panic disorder 21,229.2 1928.8 25,956.20 1309.550 <0.001 * <0.001
Hypochondriasis 147.6 13.5 192.33 32.797 <0.001 * <0.001
Posttraumatic stress disorder 1157.4 107.9 1538.40 158.457 <0.001 * <0.001
Anxiety disorder 49,638.9 4329.4 61,145.00 3890.384 <0.001 * <0.001
Anorexia nervosa 151.7 13.4 177.80 17.729 <0.001 * <0.001
Addephagia 507.9 34.0 631.20 51.985 <0.001 * <0.001
Alcoholism 2800.4 142.0 2944.40 124.962 0.003 * 0.002
Nicotine dependency 80.0 15.7 67.47 14.918 0.014 * 0.017
Gambling addiction 209.5 29.3 304.93 54.928 <0.001 * <0.001
Age 40–59 years old
Depressive disorder 93,126.1 2946.4 98,709.6 3436.8 <0.001 * <0.001
Bipolar disorder 17,747.2 650.9 18,579.3 403.8 <0.001 * <0.001
Primary insomnia 53,514.6 2709.5 58,857.4 1673.9 <0.001 * <0.001
Schizophrenia 39,003.7 913.6 37,193.2 574.2 <0.001 * <0.001
Panic disorder 33,226.0 2009.9 37,970.7 1675.0 <0.001 * <0.001
Hypochondriasis 286.6 16.8 374.6 55.5 <0.001 * <0.001
Posttraumatic stress disorder 949.5 80.0 1072.3 78.5 <0.001 * <0.001
Anxiety disorder 83,498.2 3552.9 90,802.9 3552.5 <0.001 * <0.001
Anorexia nervosa 75.3 11.4 82.5 5.4 0.024 * 0.029
Addephagia 136.4 11.7 153.3 16.2 0.002 * <0.001
Alcoholism 9555.7 286.1 8812.7 284.2 <0.001 * <0.001
Nicotine dependency 203.0 32.1 160.9 19.2 <0.001 * <0.001
Gambling addiction 69.5 7.9 87.6 11.9 <0.001 * <0.001
Age 60+ years old
Depressive disorder 128,307.4 3547.4 134,722.9 3962.8 <0.001 * <0.001
Bipolar disorder 12,665.0 770.7 13,996.6 345.2 <0.001 * <0.001
Primary insomnia 80,255.8 6311.4 93,393.3 5484.8 <0.001 * <0.001
Schizophrenia 14,972.2 636.7 16,356.7 485.1 <0.001 * <0.001
Panic disorder 14,176.7 975.5 17,413.7 1064.2 <0.001 * <0.001
Hypochondriasis 270.5 16.0 328.9 36.1 <0.001 * <0.001
Posttraumatic stress disorder 499.5 50.3 600.7 48.3 <0.001 * <0.001
Anxiety disorder 81,921.5 3288.4 92,098.7 3965.8 <0.001 * <0.001
Anorexia nervosa 377.9 83.8 468.9 41.1 0.002 * <0.001
Addephagia 46.2 6.0 47.6 9.0 0.569 <0.001
Alcoholism 6892.1 148.7 6731.9 173.4 0.007 * 0.003
Nicotine dependency 97.5 14.8 80.1 13.4 0.001 * 0.001
Gambling addiction 18.5 3.5 21.5 4.3 0.023 * 0.020

* Mann–Whitney U test, significance at <0.05. Levene’s test in non-parametric data, significance at <0.05.