Table 1.

List of established and under-development oncology therapeutics effective in experimental models of sepsis.

Host Protein	Name of the Compound	Oncology Indication	Sepsis Model	Reference
TOPO1	Topotecan Camptothecin	ovarian cancer, small cell lung cancer, cervical cancer	LPS S. aureus infection	[28]
PARP	Olaparib	ovarian cancer, breast cancer, prostate cancer, and pancreatic cancer	CLP LPS	[29,30]
MEK1/2	Trametinib	melanoma	CLP LPS	[31,32]
ERK1/2	SCH772984	melanoma colon cancer	CLP LPS	[33]
MNK1/2	Cpd 24/26 CGP57380	breast cancer, colorectal cancer, diffuse large B cell lymphoma	LPS	[34,35]
ALK	Ceritinib	non-small-cell lung cancer	CLP LPS	[36,37]
PD-1 PD-L1	Anti PD-1 Anti PD-L1	cancers with high tumor mutational burden	CLP	[38,39,40]

LPS; lipopolysaccharide, CLP; cecal ligation and puncture.