Table 1.
Genetic alterations among 34 myelodysplastic syndromes. Number of patients carrying the variant and the corresponding percentage to this number. Prevalence of mutations observed in this series and prevalence reported in the literature.
| Mutated or Rearranged Gene | Number of Patients | Percentage of Patients (%) | Overall Incidence Previous Literature (%) |
|---|---|---|---|
| ASXL1 | 11 | 31 | 15–25 |
| TET2 | 10 | 28 | 20–25 |
| SF3B1 | 6 | 17 | 20–30 |
| U2AF1 | 6 | 17 | 8–12 |
| TP53 | 5 | 14 | 8–12 |
| JAK2 | 3 | 9 | <5 |
| SRSF2 | 3 | 9 | 10–15 |
| STAG2 | 3 | 9 | 5–10 |
| IDH1/IDH2 | 3 | 9 | <10 |
| DNMT3A | 2 | 6 | 12–18 |
| EZH2 | 2 | 6 | 5–10 |
| RUNX1 | 2 | 6 | 10–15 |
| NF1 | 2 | 6 | <5 |
| ZRSR2 | 1 | 3 | 5–10 |
| CBL | 2 | 6 | <5 |
| SETBP1 | 1 | 3 | <5 |
| ETV6 | 1 | 3 | <5 |