TABLE 3.
Mutation rate and range of MIC to fluconazole in 21 strains of C. neoformans
| Strain | Total no. of cells (109) | Total no. of mutants | Mutation rate (10−9 [mean ± SD]) | Mutant MIC (μg/ml), median (range) |
|---|---|---|---|---|
| CDC-B4964 | 6.45 | 4 | 0.41 ± 0.21 | 32 (16–64) |
| CDC-MAS92-0248 | 5.93 | 0 | 0 | |
| CDC-Y195-90 | 7.28 | 73 | 6.92 ± 3.97 | 16 (16) |
| CDC-Y289-90 | 8.05 | 336 | 28.80 ± 29.24 | 8 (8–16) |
| CDC-MAS92-0316 | 0.48 | 21 | 30.17 ± 21.02 | 16 (8–16) |
| CDC-MAS92-0368 | 3.1 | 82 | 18.25 ± 8.39 | 8 (1–32) |
| CDC-MAS92-0804 | 1.5 | 21 | 9.66 ± 5.65 | 8 (4–16) |
| CDC-MAS92-0037 | 0.77 | 23 | 20.60 ± 11.12 | 8 (0.5–16) |
| CDC-MAS92-0064 | 1.91 | 180 | 80.18 ± 94.90 | 16 (4–32) |
| CDC-MAS92-0109 | 0.75 | 19 | 17.46 ± 11.18 | 4 (4–8) |
| CDC-MAS92-0245 | 0.4 | 562 | 969.44 ± 224.53 | 16 (8–16) |
| CDC-Y288-90 | 2.3 | 41 | 12.30 ± 2.37 | 16 (8–32) |
| CDC-MAS92-0232 | 0.4 | 36 | 62.10 ± 16.73 | 4 (4–8) |
| CDC-Y286-90 | 7.78 | 32 | 2.83 ± 1.01 | 8 (4–32) |
| CDC-Y290-90 | 5.3 | 122 | 15.87 ± 20.92 | 16 (8–16) |
| ATCC34875 | 21.21 | 192 | 6.24 ± 3.31 | 32 (8–64) |
| CDC-MAS92-0088 | 0.25 | 1,136 | 3,135.36 ± 98.36 | 32 (16–64) |
| CDC-MAS92-0403 | 4.93 | 0 | 0 | |
| CDC-Y494-91 | 0.28 | 664 | 1,636.28 ± 166.6 | 16 (8–16) |
| CDC-B4496 | 5.15 | 0 | 0 | |
| E275 | 0.3 | 124 | 285.19 ± 68.21 | 16 (8–32) |