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. 2022 Mar 23;14(4):234. doi: 10.3390/toxins14040234

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Percent survival of the NCI-H460 cell line as a result of treatment with O. cf. ovata fractions: (A) the aqueous (OST-AQ) and organic (OST-OR) extracts at 1 and 10 µg/mL (B) 1 and 10 µg/mL of the fractions OF1 through OF12, and (C) 5, 2, 0.5, 0.05, 0.005, and 0.0005 µg/mL of the fractions OF5 through OF10. A concentration of 1% DMSO in RPMI 1640 was chosen to serve as a negative control (set to 100% survival) in all calculations to establish consistency by matching the media DMSO composition of all the samples, while 2 µg/mL doxorubicin in RPMI 1640 served as a positive control. Statistical significance values were calculated using 2-way ANOVA function for panels (A) (p < 0.0001 ****) and (B,C) (adjusted p = 0.0001 *** and p < 0.05 *) (in GraphPad 9.3.1 GraphPad Software Inc., San Diego, CA, USA). No statistical significance was signified using ns.

Percent survival of the NCI-H460 cell line as a result of treatment with O. cf. ovata fractions: (A) the aqueous (OST-AQ) and organic (OST-OR) extracts at 1 and 10 µg/mL (B) 1 and 10 µg/mL of the fractions OF1 through OF12, and (C) 5, 2, 0.5, 0.05, 0.005, and 0.0005 µg/mL of the fractions OF5 through OF10. A concentration of 1% DMSO in RPMI 1640 was chosen to serve as a negative control (set to 100% survival) in all calculations to establish consistency by matching the media DMSO composition of all the samples, while 2 µg/mL doxorubicin in RPMI 1640 served as a positive control. Statistical significance values were calculated using 2-way ANOVA function for panels (A) (p < 0.0001 ****) and (B,C) (adjusted p = 0.0001 *** and p < 0.05 *) (in GraphPad 9.3.1 GraphPad Software Inc., San Diego, CA, USA). No statistical significance was signified using ns.