Table 3.

The relationship between the absolute change of outcomes ¹ significantly affected by dose ².

		HFCS Dose	Hepatic Lipid Content	Predicted M ISI	Matsuda ISI	Glucose OGTT AUC	Insulin OGTT AUC	Uric Acid 24 h AUC	Post-Meal Lactate AMP	Post-Meal Glucose AMP	apoCIII PP	TG 24 h AUC	TG PP	Body Weight
HFCS dose	R	1.000	0.256	−0.285	−0.238	0.372	0.371	0.608	0.632	0.406	0.385	0.319	0.521	0.303
	p-value		0.034	0.018	0.049	0.002	0.002	<0.0001	<0.0001	0.001	0.001	0.008	<0.0001	0.011
Hepatic Lipid Content	R	0.256	1.000	−0.236	−0.232	0.148	0.263	0.308	0.119	0.276	0.547	0.440	0.337	0.290
	p-value	0.034		0.051	0.056	0.226	0.029	0.010	0.330	0.022	<0.0001	0.000	0.005	0.016
Predicted M ISI	R	−0.285	−0.236	1.000	0.672	−0.638	−0.582	−0.191	−0.192	−0.057	−0.382	−0.192	−0.215	−0.152
	p-value	0.018	0.051		<0.0001	<0.0001	<0.0001	0.115	0.114	0.643	0.001	0.115	0.076	0.213
Matsuda ISI	R	−0.238	−0.232	0.672	1.000	−0.502	−0.690	−0.096	−0.293	−0.123	−0.233	−0.016	−0.127	0.163
	p-value	0.049	0.056	<0.0001		<0.0001	<0.0001	0.435	0.015	0.314	0.054	0.898	0.299	0.182
Glucose OGTT AUC	R	0.372	0.148	−0.638	−0.502	1.000	0.597	0.193	0.295	0.249	0.163	0.126	0.168	−0.013
	p-value	0.002	0.226	<0.0001	<0.0001		<0.0001	0.113	0.014	0.039	0.181	0.302	0.168	0.916
Insulin OGTT AUC	R	0.371	0.263	−0.582	−0.690	0.597	1.000	0.157	0.305	0.161	0.181	0.055	0.196	−0.055
	p-value	0.002	0.029	<0.0001	<0.0001	<0.0001		0.199	0.011	0.187	0.136	0.652	0.107	0.656
Uric acid 24 h AUC	R	0.608	0.308	−0.191	−0.096	0.193	0.157	1.000	0.304	0.314	0.296	0.166	0.259	0.347
	p-value	<0.0001	0.010	0.115	0.435	0.113	0.199		0.011	0.009	0.014	0.172	0.032	0.003
Post-meal Lactate AMP	R	0.632	0.119	−0.192	−0.293	0.295	0.305	0.304	1.000	0.464	0.230	0.124	0.266	0.020
	p-value	<0.0001	0.330	0.114	0.015	0.014	0.011	0.011		<0.0001	0.058	0.311	0.027	0.868
Post-meal Glucose AMP	R	0.406	0.276	−0.057	−0.123	0.249	0.161	0.314	0.464	1.000	0.191	0.261	0.301	0.059
	p-value	0.001	0.022	0.643	0.314	0.039	0.187	0.009	<0.0001		0.116	0.030	0.012	0.628
apoCIII PP	R	0.385	0.547	−0.382	−0.233	0.163	0.181	0.296	0.230	0.191	1.000	0.723	0.640	0.252
	p-value	0.001	<0.0001	0.001	0.054	0.181	0.136	0.014	0.058	0.116		<0.0001	<0.0001	0.037
TG 24 h AUC	R	0.319	0.440	−0.192	−0.016	0.126	0.055	0.166	0.124	0.261	0.723	1.000	0.772	0.285
	p-value	0.008	0.000	0.115	0.898	0.302	0.652	0.172	0.311	0.030	<0.0001		<0.0001	0.018
TG PP	R	0.521	0.337	−0.215	−0.127	0.168	0.196	0.259	0.266	0.301	0.640	0.772	1.000	0.184
	p-value	<0.0001	0.005	0.076	0.299	0.168	0.107	0.032	0.027	0.012	<0.0001	<0.0001		0.130
Body weight	R	0.303	0.290	−0.152	0.163	−0.013	−0.055	0.347	0.020	0.059	0.252	0.285	0.184	1.000
	p-value	0.011	0.016	0.213	0.182	0.916	0.656	0.003	0.868	0.628	0.037	0.018	0.130

¹ N = 71, includes only participants for whom all outcomes are available. ² All analyses adjusted for sex and metabolic syndrome risk factors (MSRF). HFCS, high fructose corn syrup; TG, triglyceride; ISI, insulin sensitivity index; OGTT, oral glucose tolerance test; AUC, area under the curve; AMP, amplitude; PP, postprandial.