Table 3.
Significant up and downregulated miRNAs between no or infrequent exacerbators and frequent exacerbators in the GACRS. Base Mean: normalized mean counts in reference group. Log2FC: base-2 fold change from no or infrequent to frequent exacerbators. p-value: computed with DESeq2. Beta and Odds Ratio from logistic regression are for a doubling of miR counts.
| Base Mean | log2FC | Beta | Odds Ratio | p-Value | FDR | |
|---|---|---|---|---|---|---|
| hsa-miR-451b | 18.29 | −0.524 | −0.065 | 0.57 | 1.88 × 10−4 | 2.65 × 10−2 |
| hsa-miR-142-5p | 1550.70 | −0.485 | −0.057 | 0.62 | 5.76× 10−4 | 4.15× 10−2 |
| hsa-miR-6739-3p | 11.14 | −0.458 | −0.063 | 0.64 | 8.29× 10−4 | 4.50× 10−2 |
| hsa-miR-7-5p | 1811.60 | −0.344 | −0.041 | 0.80 | 3.02× 10−3 | 9.80× 10−2 |
| hsa-miR-4433b-5p | 1759.78 | −0.308 | −0.059 | 0.80 | 2.36× 10−3 | 9.00× 10−2 |
| hsa-miR-93-3p | 8737.45 | 0.234 | 0.105 | 1.22 | 2.32×10−3 | 9.00× 10−2 |
| hsa-miR-766-3p | 294.18 | 0.246 | 0.065 | 1.31 | 2.80× 10−3 | 9.56× 10−2 |
| hsa-miR-331-3p | 1098.62 | 0.249 | 0.052 | 1.19 | 2.64× 10−3 | 9.53× 10−2 |
| hsa-miR-532-3p | 4142.15 | 0.27 | 0.102 | 1.25 | 9.33× 10−4 | 4.50× 10−2 |
| hsa-miR-664b-3p | 66.08 | 0.274 | 0.074 | 1.27 | 1.04× 10−3 | 4.50× 10−2 |
| hsa-miR-296-5p | 452.86 | 0.381 | 0.063 | 1.35 | 9.60× 10−4 | 4.50× 10−2 |
| hsa-miR-6515-3p | 19.91 | 0.385 | 0.064 | 1.43 | 4.79× 10−4 | 4.15× 10−2 |
| hsa-miR-4286 | 42.35 | 0.392 | 0.049 | 1.37 | 9.82× 10−4 | 4.50× 10−2 |
| hsa-miR-1296-5p | 31.37 | 0.411 | 0.038 | 1.31 | 9.00× 10−4 | 4.50× 10−2 |
| hsa-miR-29b-2-5p | 84.16 | 0.421 | 0.081 | 1.48 | 5.79× 10−5 | 2.65× 10−2 |
| hsa-miR-500b-5p | 193.56 | 0.425 | 0.072 | 1.59 | 1.48× 10−4 | 2.65× 10−2 |
| hsa-miR-500a-5p | 197.54 | 0.431 | 0.072 | 1.59 | 1.20× 10−4 | 2.65× 10−2 |
| hsa-miR-642a-5p | 39.54 | 0.471 | 0.045 | 1.44 | 5.20× 10−4 | 4.15× 10−2 |
| hsa-miR-103a-2-5p | 79.21 | 0.507 | 0.043 | 1.50 | 2.04× 10−4 | 2.65× 10−2 |
| hsa-miR-550a-3p | 1953.34 | 0.55 | 0.045 | 1.40 | 3.17× 10−4 | 3.43× 10−2 |