Figure 5.

Correlation of [¹⁸F]GE-180 autoradiography and TSPO immunohistochemistry in axial brain slices of a sham-operated C57BL/6 mouse. (A) TSPO staining of the glial scar at the site of the invasive inoculation; ×100. (B) TSPO staining of the ependyma; ×200. (C) TSPO staining of the hippocampal region; ×40. TSPO expression is found in CA1–CA3 neurons and the dentate gyrus. (D) TSPO staining of the cerebellum with a small portion of arachnoid mater; ×100. TSPO expression is detectable in the Purkinje cells of the cerebellum and in the arachnoid cells. (E) Anatomical correlation of sites of TSPO expression with [¹⁸F]GE-180 uptake in in vitro autoradiography.