. 2022 Apr 11;11(8):1292. doi: 10.3390/cells11081292

Table 1.

Evidence for the functional activation of TRPV1, TRPA1 and TRPC5 by reactive molecules involved in metabolic syndrome.

TRP Channel	Reactive Molecule	Cell Type	Activation Mode	Ca²⁺ Influx	Electrophysiology
TRPV1	H₂O₂	HEK293T [123,150,152]	Sensitization	✓	✓
TRPV1	H₂O₂	Bovine aortic endothelial cells [123]	Sensitization	✓
TRPA1	H₂O₂	HEK293T [157,158,159]	Direct	✓
		DRG neurones [158,159,160]	Direct	✓
		Bladder neuronal afferents [161]	Direct		✓
		CHO cells [160]	Direct	✓
	NO	HEK293T [159]	Direct	✓
	NO	DRG neurones [159]	Direct	✓
	H+	HEK293T [159]	Direct	✓
	H+	DRG neurones [159]	Direct	✓
	Aldehydes (4-HNE and 4-ONE)	HEK293T cells [157]	Direct	✓
		DRG and trigeminal ganglia neurones [157,160]	Direct	✓
		CHO cells [160,162]	Direct	✓
TRPC5	H₂O₂	HEK293T cells [145]	Direct	✓
	Reduced TRX	HEK293T cells [150]	Direct	✓
	Reduced TRX	Synoviocytes [150]	Direct	✓