Table 2.
Evidence for TRPV1, TRPA1 and TRPC5 expression on cells and in tissues involved in metabolic syndrome.
| TRP Channel | Cell/Tissue | PCR/ qPCR |
Immunostaining/ Immunofluorescence |
Western Blot | Ca2+
Influx |
Electrophysiology |
|---|---|---|---|---|---|---|
| TRPV1 | adipose tissue/adipocytes [124,125,200,201] | ✓ | ✓ | ✓ | ✓ | |
| liver [126,127] | ✓ | ✓ | ✓ | ✓ | ||
| M1 macrophages [128] | ✓ | ✓ | ||||
| pancreatic β-cells/langerhans islets [132] | ✓ | ✓ | ✓ | |||
| coronary endothelial cells [123] | ✓ | |||||
| T cells [129,130,131] | ✓ | ✓ | ✓ | ✓ | ||
| skeletal muscle [202,203,204] | ✓ | ✓ | ✓ | ✓ | ||
| pro-opiomelanocortin neurones [205] | ✓ | ✓ | ✓ | ✓ | ||
| TRPA1 | pancreatic β-cells/langerhans islets [137,206] | ✓ | ✓ | ✓ | ✓ | ✓ |
| T cells [175,176,177] | ✓ | ✓ | ✓ | ✓ | ✓ | |
| skeletal muscle cells [207] | ✓ | ✓ | ✓ | ✓ | ✓ | |
| monocytes/macrophages [179,180] | ✓ | ✓ | ✓ | ✓ | ||
| TRPC5 | endothelial cells [166] | ✓ | ||||
| T cells [185] | ✓ | ✓ | ||||
| M1 macrophages [186] | ✓ | ✓ | ||||
| pancreas [208] | ✓ | |||||
| adipose tissue [147,200] | ✓ | ✓ | ✓ | ✓ | ✓ | |
| pro-opiomelanocortin neurones [209,210,211] | ✓ |