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. 2022 Apr 14;11(8):1345. doi: 10.3390/cells11081345

Table 2.

Clinical features associated with myosteatosis.

Characteristics Myosteatosis (n = 295) No Myosteatosis (n = 560) p-Value
Age (years) 57 ± 8 56 ± 9 0.02
Sex, male 189 (64) 346 (62) 0.55
Cirrhosis etiology
  • -

    Alcohol

 95 (32) 120 (21) 0.001
  • -

    Hepatitis C

 103 (35) 233 (42) 0.07
  • -

    Hepatitis B

 7 (2) 48 (9) <0.001
  • -

    NASH

 66 (22) 105 (19) 0.21
  • -

    Autoimmune liver disease

 21 (7) 50 (9) 0.43
Albumin (g/L) 32 ± 7 32 ± 6 0.37
MELD score 17 ± 9 14 ± 7 <0.001
Refractory Ascites 100 (34) 133 (24) 0.002
Sodium (mmol/L) 135 ± 8 136 ± 5 0.006
Encephalopathy 135 (46) 183 (33) <0.001
Variceal bleeding 47 (16) 108 (19) 0.26
Diabetes 46 (16) 65 (12) 0.11
HCC 112 (38) 243 (43) 0.14
BMI, kg/m2 28 ± 6 27 ± 5 <0.001
Skeletal muscle radiodensity, HU 25 ± 6 39 ± 6 <0.001
* Sarcopenia 148 (50) 177 (32) <0.001

Abbreviations: BMI, body mass index; HCC, hepatocellular carcinoma; HU, Hounsfield units; MELD, model for end-stage liver disease; NASH, non-alcoholic steatohepatitis; * Sarcopenia was defined using established cut-offs in patients with cirrhosis as skeletal muscle index < 50 cm2/m2 in males and <39 cm2/m2 in females [17]. Myosteatosis was established as muscle radiodensity <33 HU in males and <28 HU in females.