Table 2.
Summary of methods used in studies.
|
Summary of Studies Overview of Common Methods |
||
|---|---|---|
| Type/Method | No. of Studies | |
| Type of NPs | Polymeric | 55 |
| Lipid | 12 | |
| MSN | 13 | |
| Metallic | 11 | |
| Other | 29 | |
| pH Sensitization Method | pH-labile linkers | 70 |
| pH-triggered structural changes | 35 | |
| pH-triggered hydrophobic to hydrophilic transition | 8 | |
| Other methods | 7 | |
| Cancer Model | Breast malignant cell lines (4T1, MCF-7, MDA-MB-231) |
48 |
| Cervical malignant cell lines (HeLA) |
8 | |
| Lung malignant cell lines (A549) |
14 | |
| Colorectal malignant cell lines (CT-26, HCT116, SW480) |
8 | |
| Liver malignant cell lines (H22, HepG2, SMMC 7721) |
17 | |
| Other | 25 | |
| Types of Chemotherapeutics | Doxorubicin | 69 |
| Paclitaxel | 9 | |
| Other | 42 | |