Table 1.

Stratification and time point for audiological examination based on treatment.

	Audiological assessment
Treatment	Stratum	Before start treatment	During treatmenta	Within 3 months after treatment
Platinum agents (cisplatin, carboplatin, oxaliplatin)	1	✓b	✓	✓
CNSc/ENTd irradiation	1e	✓		✓
CNS/ENT surgery	1e	✓		✓
No platinum agents, CNS/ENT irradiation, or CNS/ENT treatment	2	✓		✓

^aTime points for audiological assessments during treatment are based on recommendations in the childhood cancer treatment protocol.

^bThe checkmark indicates that the assessment was performed at this time point.

^cCNS: central nervous system.

^dENT: ear-nose-throat.

^ePatients are included in stratum 1 if audiological examinations are part of standard care; otherwise, they are included in stratum 2.