Comparison of previously reported methods for the simultaneous determination of analytesa.
| Sample preparation and determination | Sample | Analytes | pKa | Log P | LOD (μg L−1) | LOQ (μg L−1) | Recovery (%) | Ref. |
|---|---|---|---|---|---|---|---|---|
| IP SPE-IP LC | Plasma | MET | — | — | 3 | 5 | 97.9–100.5 | 51 |
| SPE-non-aqueous CE | Plasma | MET | 131 | — | 12 | — | — | 54 |
| PHEN | 12.7 | 6 | — | — | ||||
| IP SPE-HPLC MS | Plasma | MET | — | −1.80 | — | 2.49 | 86.1 | 55 |
| Bar-μ-SPE-HPLC UV | Urine | MET | 11.5 | −1.82 | 4.03 | 12.2 | 75.1–85.4 | This work |
| BUF | 12.3 | −0.03 | 3.94 | 11.9 | 72.8–84.6 | |||
| PHEN | 11.8 | 0.41 | 6.90 | 20.9 | 109–116 | |||
| SPE-LC ESI/MS MS | Plasma | PROP | — | — | 0.05 | 0.20 | 96.4–98.5 | 52 |
| 4-HYD PROP | — | — | 0.10 | 0.20 | 64.7–66.2 | |||
| EME-GC MC | Wastewater | PROP | — | — | 0.0081 | — | 80.0 | 14 |
| NOR | — | — | 0.13 | — | 18.0 | |||
| IBU | — | — | 0.13 | — | 20.0 | |||
| ALP | — | — | 0.18 | — | 23.0 | |||
| NAP | — | — | 0.26 | — | 26.0 | |||
| KETO | 4.2–9.5 | — | 0.027 | — | 40.0 | |||
| MIP SBSE-HPLC UV | Urine | PROP | 9.50 | 2.90 | 0.37 | 1.0 | 86.8–106 | 56 |
| SPE-UHPLC UV | Urine | PROP | — | — | 19 | 59 | 85.5–105 | 53 |
| Bar-μ-SPE-HPLC UV | Urine | PROP | 9.49 | 3.10 | 17.0 | 51.6 | 97.0–116 | This work |
a
Abbreviations: MISPE: molecularly imprinted solid phase extraction, MIP: molecularly imprinted polymer, TFA: trifluoroacetic acid, IP SPE: ion pair solid phase extraction, IP LC: ion pair liquid chromatography, 4-HYD PROP: 4-hydroxy propranolol, EME: electromembrane extraction, NOR: norephedrine, IBU: ibuprofen, ALP: alprenolol, NAP: naproxen, KETO: ketoprofen, MIP SBSE: molecularly imprinted polymer stir-bar sorptive extraction, UHPLC: ultra high-performance liquid chromatography, ESI: electrospray ionization, MS: mass spectrometry.