Table 2.
Dysregulated proteins between PCa patients and cancer-free subjects (MaxQuant).
| Uniprot ID | Protein Name | Gene Name | p-Value | Cohen’s d [Lower; Upper 95% CI] |
|---|---|---|---|---|
| Q8WVN6 | Secreted and transmembrane protein 1 | SECTM1 | 0.01 | −2.10 (−2.48; −1.73) |
| P07288 | Prostate-specific antigen | KLK3 | 0.01 | 2.01 (1.08; 2.95) |
| P41222 | Prostaglandin-H2 D-isomerase | PTGDS | 0.01 | −1.97 (−2.44; −1.49) |
| Q14624 | Inter-alpha-trypsin inhibitor heavy chain H4 | ITIH4 | 0.01 | −1.96 (−2.32; −1.60) |
| Q12805 | EGF-containing fibulin-like extracellular matrix protein 1 | EFEMP1 | 0.01 | −1.84 (−2.33; −1.35) |
| P55290 | Cadherin-13 | CDH13 | 0.02 | −1.75 (−2.11; −1.40) |
| P98160 | Basement membrane-specific heparan sulfate proteoglycan core protein | HSPG2 | 0.03 | −1.63 (−2.07; −1.19) |
| P04746 | Pancreatic alpha -amylase | AMY2A | 0.03 | −1.57 (−1.95; −1.19) |
| P01876 | Immunoglobulin heavy constant alpha 1 | IGHA1 | 0.04 | 1.55 (1.32; 1.78) |
| P02760 | Protein AMBP | AMBP | 0.04 | −1.51 (−1.88; −1.13) |
| P12830 | Cadherin-1 | CDH1 | 0.05 | −1.48 (−1.90; −1.07) |
| Q12907 | Vesicular integral-membrane protein VIP36 | LMAN2 | 0.05 | −1.46 (−2.10; −0.83) |
| Q9NPP6 | Immunoglobulin heavy chain variant | N/A | 0.04 | 1.58 (1.22; 1.93) |
| P02766 | Transthyretin | TTR | 0.05 | 1.42 (0.97; 1.87) |
The protein identification and label-free quantification performed by the MaxQuant software revealed fourteen dysregulated proteins (p-value ≤ 0.05) between the tested groups. These proteins are shown in this table along with their p-value and effect size. The Cohen’s d fof individual proteins is presented together with the lower and upper 95% confidence interval (CI). Abbreviation: Confidence interval (CI).