Table 4.

Results of Polyphen-2 score and prediction for the mapped mutations.

Gene Name	Mutation	Prediction	Score	Sensitivity	Specificity
AMBP	G238S	Probably damaging	1.000	0.00	1.00
AMBP	E192G	Probably damaging	0.75	0.981	0.96
AMBP	V69M	Possibly damaging	0.758	0.85	0.92
AMBP	A286G	Probably damaging	1.000	0.00	1.00
AMBP	P197S	Benign	0.051	0.94	0.83
AMBP	G338S	Probably damaging	0.994	0.69	0.97
AMBP	G341A	Probably damaging	0.958	0.78	0.95
AMBP	V313I	Benign	0.025	0.95	0.81
AMBP	G186R	Probably damaging	1.000	0.00	1.00
AMBP	R185Q	Probably damaging	0.992	0.70	0.97
CDH1	H233R	Possibly damaging	0.831	0.84	0.93
CDH1	A408E	Possibly damaging	0.798	0.84	0.93
EFEMP1	V463M	Probably damaging	0.999	0.14	0.99
HSPG2	V4332I	Benign	0.001	0.99	0.15
HSPG2	A1503V	Probably damaging	1.00	0.00	1.00
HSPG2	S970F	Possibly damaging	0.498	0.88	0.90
HSPG2	M638V	Benign	0.00	1.00	0.00
HSPG2	Q1062H	Benign	0.00	1.00	0.00
ITIH4	R866C	Probably damaging	1	0.00	1.00
ITIH4	G893S	Benign	0.00	1.00	0.00
KLK3	C209Y	Probably damaging	1.000	0.00	1.00
KLK3	G156V	Probably damaging	1.000	0.00	1.00
KLK3	V55M	Probably damaging	0.972	0.77	0.96
KLK3	S117P	Possibly damaging	0.621	0.87	0.91
KLK3	G87R	Benign	0.128	0.93	0.86
KLK3	L124F	Probably damaging	1.000	0.00	1.00
KLK3	A154T	Possibly damaging	0.657	0.86	0.91
KLK3	I 179T	Possibly damaging	0.800	0.84	0.93
LMAN2	G250S	Probably damaging	1.00	0.00	1.00
LMAN2	D229N	Probably damaging	0.983	0.74	0.96
PTGDS	L130M	Probably damaging	1.00	0.00	1.00
ASAH1	V246A	Benign	0.00	1.00	0.00
SOD3	A58T	Benign	0.188	0.92	0.87
GSTP1	I105V	Benign	0.00	1.00	0.00
SPP1	A22G	Possibly damaging	0.611	0.87	0.91
ACP3	G68D	Probably damaging	1.00	0.00	1.00
AZGP1	P187L	Probably damaging	0.94	0.69	0.97
AZGP1	A46T	Benign	0.002	0.99	0.30
SLC9B1	N70S	Benign	0.036	0.94	0.82
ZNF624	S207F	Benign	0.214	0.92	0.88
VASN	R161Q	Benign	0.019	0.95	0.80
CD55	S162L	Probably damaging	0.990	0.72	0.97