Table 1.
Clinicopathological characteristics of the breast carcinoma cases analyzed in the study.
| Tumor Characteristics | Value | Nr. (%) of Patients for TIL Assessment (309 Cases) | Nr. (%) of Patients for CD4 and CD8 Double Staining (75 Cases) |
|---|---|---|---|
| Age at diagnosis | ≤50 year | 78 (25.24%) | 22 (29.33%) |
| >50 year | 231 (74.75%) | 53 (70.66%) | |
| pT | pT1 | 148 (47.90%) | 32 (42.67%) |
| pT2 | 130 (42.07%) | 35 (46.67%) | |
| pT3 | 19 (6.15%) | 4 (5.33%) | |
| pT4 | 12 (3.88%) | 4 (5.33%) | |
| pN | pN0 | 136 (44.01%) | 24 (32.00%) |
| pN1 | 91 (29.45%) | 27 (36.00%) | |
| pN2 | 31 (10.03%) | 8 (10.67%) | |
| pN3 | 18 (5.83%) | 10 (13.33%) | |
| pNx | 33 (10.68%) | 6 (8.00%) | |
| Tumor grade | 1 | 62 (20.06%) | 9 (12.00%) |
| 2 | 131 (42.39%) | 22 (29.33%) | |
| 3 | 116 (37.54%) | 44 (58.67%) | |
| Subtype | LUMA | 87 (28.16%) | 13 (17.33%) |
| LUMB1 | 98 (31.72%) | 20 (26.67%) | |
| LUMB2 | 30 (9.71%) | 8 (10.67%) | |
| HER2 | 30 (9.71%) | 10 (13.33%) | |
| TNBC | 60 (19.42%) | 22 (29.33%) | |
| No data | 4 (1.29%) | 2 (2.67%) | |
| Histological type | Invasive ductal carcinoma of no special type (IDC-NST) | 271 (87.70%) | 71 (94.67%) |
| Invasive lobular carcinoma (ILC) | 25 (8.09%) | 3 (4.00%) | |
| Other | 13 (4.21%) | 1 (1.33%) | |
| Recurrences | YES | 78 (25.24%) | 34 (45.33%) |
| NO | 227 (73.46%) | 41 (54.67%) | |
| No data | 4 (1.29%) | 0 (0.00 %) | |
| Distant metastasis | YES | 65 (21.04%) | 33 (44.00%) |
| NO | 240 (77.67%) | 42 (56.00%) | |
| No data | 4 (1.29%) | 0 (0.00%) | |
| pTIL (score) | 0 | 0 (0.00%) | 0 (0.00%) |
| 1 | 225 (72.82%) | 40 (53.33%) | |
| 2 | 65 (21.04%) | 25 (33.33%) | |
| 3 | 19 (6.15%) | 10 (13.33%) | |
| sTIL | <5% | 110 (35.60%) | 10 (13.33%) |
| 5–10% | 128 (41.42%) | 34 (45.33%) | |
| 11–20% | 44 (14.24%) | 21 (28.00%) | |
| >20% | 27 (8.74%) | 10 (13.33%) | |
| iTIL (count) | <2 | 152 (49.19%) | 20 (26.67%) |
| ≥2 | 157 (50.81%) | 55 (73.33%) |