Table 3.
Modulatory effect of Ornipural® against the harmful impact of malathion on hepato-renal functional biomarkers in the serum.
| Control | Corn Oil Group | Malathion | Malathion + Ornipural® | Ornipural® | |
|---|---|---|---|---|---|
| AST (U/mL) | 80.58 ± 5.2 | 79.00 ± 5.9 | 172.86 ± 8.6 ## | 89.82 ± 4.5 *+ | 75.26 ± 2.3 |
| ALT (U/mL) | 35.15 ± 3.1 | 34.46 ± 2.5 | 77.07 ± 4.2 ## | 48.43 ± 3.2 *+ | 36.29 ± 1.5 |
| ALP (U/L) | 85.20 ± 4.45 | 83.53 ± 3.6 | 202.49 ± 15.14 ## | 99.82 ± 5.3 **+ | 77.88 ± 4.6 & |
| LDH (U/L) | 194.66 ± 10.2 | 195.75 ± 12.3 | 431.95 ± 17.2 ## | 298.03 ± 10.2 **+ | 192.87 ± 9.01 |
| ACP(U/L) | 101.12 ± 11.2 | 102.14 ± 10.2 | 181.3 ± 10.14 ## | 119.34 ± 10.45 *+ | 100.14 ± 2.9 |
| Bilirubin (mg/dL) | 5.22 ± 0.14 | 5.10 ± 0.10 | 7.15 ± 0.6 # | 6.12 ± 0.4 *+ | 5.01 ± 0.4 |
| Total protein (g/L) | 5.10 ± 0.5 | 5.00 ± 0.1 | 3.42 ± 0.4 # | 4.20 ± 0.2 *+ | 4.95 ± 0.5 |
| Albumin (g/L) | 4.02 ± 0.4 | 3.94 ± 0.6 | 2.92 ± 0.1 # | 3.47 ± 0.1 *+ | 3.91 ± 0.1 |
| Triglycerides (g/L) | 110.29 ± 6.3 | 108.12 ± 10.4 | 67.78 ± 1.3 ## | 84.23 ± 4.5 *+ | 105.05 ± 3.8 |
| HDL-C (mg/dL) | 65.84 ± 4.45 | 63.01 ± 6.48 | 49.12 ± 3.8 ## | 53.14 ± 4.7 *+ | 66.8 ± 5.6 |
| LDL-C (mg/dL) | 101.14 ± 6.1 | 100.4 ± 6.2 | 125.14 ± 6.4 ## | 114.12 ± 4.5 *+ | 99.15 ± 5.2 |
| Cholesterol (mg/dL) | 77.44 ± 4.6 | 79.88 ± 3.4 | 149.10 ± 9.5 ## | 104.20 ± 5.6 *+ | 71.19 ± 3.5 & |
| Uric acid (mg/dL) | 25.46 ± 3.6 | 24.96 ± 1.01 | 80.05 ± 7.5 ## | 41.05 ± 2.5 *+ | 20.97 ± 1.01 |
| Urea (mg/dL) | 21.83 ± 2.3 | 21.40 ± 1.0 | 73.99 ± 4.5 ## | 40.26 ± 3.2 *+ | 18.35 ± 1.04 |
| Creatinine (mg %) | 0.66 ± 0.01 | 0.64 ± 0.01 | 2.05 ± 0.3 # | 1.76 ± 0.1 *+ | 0.57 ± 0.1 |
| AChE (U/L) | 250.01 ± 10.15 | 245.15 ± 11.2 | 75.96 ± 5.8 ## | 126.15 ± 6.48 *+ | 233.15 ± 12.4 |
| Paraoxonase (U/L) | 176.14 ± 13.1 | 177.5 ± 12.4 | 120.14 ± 5.4 ## | 138.56 ± 7.14 *+ | 181.14 ± 13.1 |
| Ammonia (μmol/L) | 128.15 ± 10.12 | 131.14 ± 9.48 | 256.1 ± 17.69 ## | 186.14 ± 12.14 **+ | 130.14 ± 12.69 |
Data are expressed as mean ± S.E.M. The statistical analysis was performed using one-way ANOVA, followed by Duncan’s multiple range test. # p < 0.05, and ## p < 0.01. control/sham vs. malathion. * p < 0.05 and ** p < 0.01 malathion vs. malathion and Ornipural®. + p < 0.05 control/sham vs. malathion and Ornipural®. & p < 0.05 control/sham vs. Ornipural®.