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. 2022 Apr 18;11(4):613. doi: 10.3390/biology11040613

Figure 4.

Figure 4

There were larger resurgent Na+ currents in the p.V781I and p.A1737T channels than in the WT channel. (A) In the presence of 0.1 mM Navβ4 peptide in the extracellular medium, cells were patched at −120 mV, and the resurgent Na+ currents were measured at the repolarization stage by applying a stepwise voltage escalating from 0 and −120 mV in 10 mV increments, following a +40 mV depolarizing prepulse. (B) The population results (n = 8) were obtained in the experiment in part A. There was a significant difference in the resurgent to peak transient current ratios (I resurgent/I transient) between the WT and the p.V781I and p.A1737T mutant channels at all repolarization potentials, between −70 and −10 mV (* p < 0.05 and ** p < 0.01).