Table 2.
ICSI or IVF as fertilization methods applied in male and non-male factors infertility. ICSI: intracytoplasmic sperm injection; IVF: in vitro fertilization; OAT: oligoasthenoteratozoospermia. Adapted with permission from Ref [43].
| Infertility Factor | Method of Fertilization | Study [Ref] |
|---|---|---|
| Male factor infertility | ||
| Azoospermia | ICSI mandatory | [86,92,94,95] |
| Moderate OAT | IVF and ICSI equally effective | [83,85] |
| Severe OAT | ICSI highly recommended | [81,91,92] |
| Absolute asthenozoospermia | ICSI mandatory | [91,92] |
| Antisperm antibodies | IVF and ICSI equally effective | [106,107,108] |
| Sperm DNA fragmentation | ICSI recommended | [106,107,110] |
| Globozoospermia | ICSI mandatory | [111,112] |
| Non-male factor infertility | ||
| General non-male factor | Equally effective, slightly in favor of IVF | [113,114,115] |
| Preimplantational genetic testing | ICSI highly recommended | [84,124] |
| Unexplained infertility | Equally effective | [117,118,119] |
| Poor responders | Equally effective, slightly in favor of IVF | [119,120] |
| Poor oocyte quality | Equally effective, slightly in favor of IVF | [117,121,122] |
| Advanced maternal age | Equally effective, slightly in favor of IVF | [120,122,123] |