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. Author manuscript; available in PMC: 2022 Nov 15.

Published in final edited form as: Nat Nanotechnol. 2021 Nov 10;16(11):1180–1194. doi: 10.1038/s41565-021-01017-9

Figure 5. — A) Ferumoxytol iron oxide nanoparticles modulate macrophage polarization in tumors, driving M1 polarization and inducing killing of cancer cells via extracellular ROS generation. [Reprint figure adapted from PMID 27668797] B) Ferumoxytol uptake by iron-retaining leukemic cells activates the ferroptotic pathway, triggering cell death. [Reprint figure from PMID 30911166] C) Titanium dioxide nanoparticles modulate endothelial cell permissiveness in microvasculature and facilitate cancer metastasis. [Reprint figure from PMID 30692675] D) C-dots accumulate iron content in vivo, triggering ferroptotic cell death in cancer cells. [Reprint figure adapted from PMID 27668797]

Figure 5. — A) Ferumoxytol iron oxide nanoparticles modulate macrophage polarization in tumors, driving M1 polarization and inducing killing of cancer cells via extracellular ROS generation. [Reprint figure adapted from PMID 27668797] B) Ferumoxytol uptake by iron-retaining leukemic cells activates the ferroptotic pathway, triggering cell death. [Reprint figure from PMID 30911166] C) Titanium dioxide nanoparticles modulate endothelial cell permissiveness in microvasculature and facilitate cancer metastasis. [Reprint figure from PMID 30692675] D) C-dots accumulate iron content in vivo, triggering ferroptotic cell death in cancer cells. [Reprint figure adapted from PMID 27668797]