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. 2022 Mar 31;12(4):533. doi: 10.3390/biom12040533

Figure 1.

Figure 1

KinDel candidates that influence α-arrestin-dependent phenotypes: (a) Growth of serial dilutions of WT cells containing the indicated pRS426-derived plasmids expressing either nothing (vector) or the indicated α-arrestin on SC medium lacking uracil and containing 1.5M NaCl or 50 ng/mL rapamycin. (b–d) Venn diagrams indicating the number of KinDel library gen deletions found to alter the sensitivity of (b) Aly1 or (c) Aly2 on control (yellow), high-salt (red), or rapamycin (blue) medium. The sum of the numbers in each circle identifies the number of gene deletions in each class. Panel (d) shows the overlapping candidates identified in both the Aly1 and Aly2 screens for each medium condition.