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Comparison of PAC and STRAP with FASP. (A) Efficacy of tryptic digestion shown by percentage of missed cleavages. (B) Intra-method %CVs based on all quantified proteins, median %CVs are given. (C) Hierarchical clustering [49] of all quantified proteins, colors reflect log2-normalized abundances. (D–F) Volcano plots highlighting proteins that were significantly enriched by either method (multiple hypothesis testing using FDR-based approach by Benjamini–Krieger, FDR 1%).
