TABLE 4.
Density of C. albicans in kidneys of rabbits that received 2, 5, 13, and 21 days of antifungal drug therapya
| Antifungal regimen | Density of C. albicansb (no. of animals) for treatment period
|
|||
|---|---|---|---|---|
| 2 days | 5 days | 13 days | 21 days | |
| Control | 3.97 ± 0.28+ (6) | 4.26 ± 0.26∗∗ (8) | — | — |
| FLC | 3.60 ± 0.34+ (6) | 3.55 ± 0.26∗∗ (12) | 2.34 ± 0.31∗ (7) | 0 (5) |
| FLC→AMB+FLC | 3.52 ± 0.38+ (6) | 3.20 ± 0.17∗∗ (8) | 2.31 ± 0.22∗ (7) | 0 (5) |
| FLC→AMB | 3.55 ± 0.42+ (6) | 0 (6) | 0 (6) | 0 (2) |
| FLC+AMB(simult) | 3.39 ± 0.44+ (6) | 3.29 ± 0.46∗∗ (8) | 0 (6) | 0 (2) |
| AMB→FLC | 2.36 ± 0.41 (6) | 1.86 ± 0.34+ (7) | 0 (6) | 0 (2) |
| AMB→AMB+FLC | 2.14 ± 0.25 (6) | 0 (8) | 0 (6) | 0 (2) |
| AMB | 2.27 ± 0.33 (6) | 0 (8) | 0 (7) | 0 (5) |
a
Symbols: —, not done; +, P < 0.05 versus results for AMB; ∗, P < 0.001 versus results for AMB; ∗∗, P < 0.0005 versus results for AMB.
b
Densities are expressed as log10 CFU ± 1 standard error of the mean.