TABLE 5.
Effect of using FLC treatment for 1 or 5 days prior to switching to AMB+FLC or AMB on C. albicans density in cardiac vegetations and kidneys
| Antifungal regimen for: |
C. albicans densitya for no. of days of therapy after switch from FLC treatmentb
|
|||
|---|---|---|---|---|
| 2 days | 5 days | 8 days | 13 days | |
| Cardiac vegetations | ||||
| FLC(1 day)→FLC | 4.43 ± 0.47 | 4.19 ± 0.38 | 3.92 ± 0.35 | |
| FLC(1 day)→AMB+FLC | 4.31 ± 0.21 | 4.22 ± 0.47 | 4.06 ± 0.54 | |
| FLC(5 days)→AMB+FLC | 4.28 ± 0.42 | 4.16 ± 0.33 | 3.83 ± 0.48 | |
| FLC(1 day)→AMB | 2.33 ± 0.52 | 0.84 ± 0.30#+ | 0# | |
| FLC(5 days)→AMB | 3.61 ± 0.44 | 3.15 ± 0.29 | 0# | |
| AMB alone | 0.41 ± 0.36#+ | 0#+ | 0# | |
| Kidneys | ||||
| FLC(1 day)→FLC | 3.84 ± 0.35 | 3.90 ± 0.22 | 3.36 ± 0.39 | 2.73 ± 0.54 |
| FLC(1 day)→AMB+FLC | 3.66 ± 0.47 | 3.41 ± 0.29 | 3.25 ± 0.47 | 2.46 ± 0.38 |
| FLC(5 days)→AMB+FLC | 3.88 ± 0.50 | 3.60 ± 0.38 | 4.16 ± 0.33 | 2.59 ± 0.47 |
| FLC(1 day)→AMB | 3.54 ± 0.33 | 1.06 ± 0.30#+ | 0# | 0# |
| FLC(5 days)→AMB | 3.47 ± 0.43 | 2.88 ± 0.25# | 1.64 ± 0.33# | 0# |
| AMB alone | 1.82 ± 0.27#+ | 0#+ | 0# | 0# |
a
Densities are expressed as log10 CFU ± 1 standard error of the mean.
b
For FLC(1 day)→AMB, FLC(5 days)→AMB, FLC(1 day)→AMB+FLC, and FLC(5 days)→AMB+FLC, treatment days were standardized to the number of days that treatment was given after FLC was switched to AMB alone or AMB+FLC. For animals that received only AMB or FLC, treatment days are referenced to when antifungal treatment was begun. Symbols: #, P < 0.05 versus results for FLC; +, P < 0.05 versus results for FLC(5 days)→AMB.