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Transcriptional cofactors are required for the ZEB1 function. (A) ZEB1 interacts with co-repressors to repress the transcription of their target genes. BRG1 binds to the CBD, and CtBP binds to the CID, but the binding site of the NuRD complex is still unknown; (B) ZEB1 interacts with co-activators to activate the transcription of their target genes. p300-P/CAF and YAP bind to the CBD. P300 forms a complex with Smad (Smad-P300) in response to TGF-β via its SID.
