Figure 2.

The amount of alcohol consumed by mice is influenced by sex, genotype, and number of drinking days, but not L:D cycles. (A). Female WT and Clock^Δ19/Δ19 mice, regardless of L:D cycles, showed no differences in the amount of alcohol consumed over time. (B). Over time, the amount of alcohol consumed by male Clock^Δ19/Δ19 mice increased such that they were consuming more than the male WT mice for most of the study period. (C). The amount of alcohol consumed by female mice diverged from that of male WT mice across the 20-day testing period. (D). Female and male Clock^Δ19/Δ19 mice demonstrated similar amounts of alcohol consumed across the 20-day testing period. F = females, M = males; 12 = 12:12 L:D cycle, 10 = 10:10 L:D cycle; WT = wild-type. Darker tones are WT mice and lighter tones are Clock^Δ19/Δ19 mice. Black = female 12:12 L:D group, blue = female 10:10 L:D group, purple = male 12:12 L:D group, orange = male 10:10 L:D group. * = p < 0.05, *** = p < 0.001.