TABLE 5.

Summary of hypericin peak and trough concentrations

Patient no.	Dose (mg/kg)	Mean Cmaxa ± SD (ng/ml)	Mean Cminb ± SD (ng/ml)	Mean Cmin, endc ± SD (ng/ml)
1	0.05	32.7	21.3 ± 4.0	21.4 ± 0.6
2	0.05	16.7	10.9
3	0.05	17.5	12.7 ± 0.7	13.6
4	0.05	39.2	25.6 ± 1.4	24.6 ± 2.6
5	0.05	21.1	16.7 ± 4.3
6	0.05	54.9	18.9 ± 4.0	20.4
7	0.05	19.6	11.1
8	0.05	18.4	9.9
9	0.05	35.3 ± 4.1	21.5 ± 7.8	11.6
10	0.05	25.6	13.0 ± 2.9	20.3 ± 1.2
11	0.05	19.0	9.2
12	0.05	36.8 ± 0.1	13.9 ± 4.5	14.1 ± 0.3
Mean		28.1	15.4	18.0
Median		4.0	13.5	20.3
SD		11.8	5.3	4.9
13	0.10	79.2	28.5 ± 8.4	25.5 ± 6.9
14	0.10	66.3	39.4 ± 3.8	42.2 ± 5.1
15	0.10	78.5 ± 11.1	40.8 ± 7.3	47.0 ± 1.6
16	0.10	30.4	19.7 ± 5.3	21.2 ± 2.5
17	0.10	66.6	41.7 ± 5.8
18	0.10	112.4	47.7 ± 6.0	48.8 ± 2.8
19	0.10	120.9 ± 10.4	71.9 ± 14.5	85
Mean		79.2	41.7	45.0
Median		78.5	40.8	44.6
SD		30.4	15.9	22.7

^aAverage of values from days 7 and 14, when available. 

^bAverage of values from days 7, 14, and 28, when available. 

^cC_{min, end}, C_min at end of treatment cycle.