TABLE 6.

Hypericin pharmacokinetic parameter estimates^a

Patient no.	Dose (mg/kg)	Tmax	Cmax	AUC (μg/ml × h)	Elimination t1/2 (h)b	V/F (liter)c	CLTB (ml/ min/m2)d
1	0.05	2.6	46.4	1.75	24.1	14.0	4.7
2	0.05	8.1	13.3	1.03	36.8	36.0	7.1
3	0.05	3.7	18.1	1.37	65.7	48.4	5.3
4	0.05	3.1	29.3	2.87	65.8	22.5	2.2
6	0.05	2.7	24.9	1.32	34.8	28.2	4.5
10	0.05	2.2	42.6	1.02	19.3	24.0	8.1
12	0.05	8.7	39.3	0.93	6.3	13.9	8.9
Mean		4.4	30.6	1.5	36.1	26.7	5.8
Median		3.1	29.3	1.3	34.8	24.0	5.3
SD		2.7	12.6	0.7	22.6	12.3	2.3
13	0.10	5.9	42.1	1.82	22.6	109.0	22.8
15	0.10	6.9	69.4	4.86	37.4	71.9	9.8
16	0.10	3.3	30.0	2.64	58.6	112.1	11.9
18	0.10	1.6	118.0	2.99	16.4	44.0	10.5
Mean		4.4	64.9	3.1	33.8	84.3	13.4
Median		4.6	55.8	2.8	30.0	90.5	11.2
SD		2.4	39.1	1.3	18.8	32.5	6.4

^aT_max, time to C_max. 

^bt_1/2, half-life. 

^cV/F, volume of distribution/bioavailability. 

^dCL_TB, total body clearance.